This sounds like feedback from your radio transmitter to your audio system.
We've seen this happen for a variety of reasons. This usually means a lot of RF energy from your radio transmitter is getting into your audio system. Things to try:
1) Turn the intercom off (press the power button). Does it still happen? It might be your headsets themselves. We've seen noise-canceling headsets do this before.
2) Unplug all but one headset, and then try it in the pilot and co-pilot side. Does it only happen on one side?
3) Unplug just the mic jack but leave the headphone jack plugged in. Does it still do it?
Where is the antenna on your plane and what kind of plane?