A person with average mechanical abilities, with basic tools can accomplish this installation. Heck, if you've installed a car stereo you can do this.
We installed the D100 in the RV6 last Nov. And it did take some time to do, but not because it's hard, but because we spent lots of time figuring out where to put things and how/where to run wires and lines.
We didn't have to "re-do" the whole panel. The EFIS will take up the space of two 3 inch instruments. Because of the way our panel was laid out, we determined that the best place to locate the EFIS was right where the Altimeter and Airspeed instruments were. So what we did was to remove the T&B and VS instruments (cause the EFIS has these functions anyway) and we moved the Altimeter and Airspeed instruments into their place (the Altimeter and Airspeed are now used as standby/comparison instruments). That gave us two 3" holes that we opened up to the rectangular dimensions of the EFIS tray. Some time was spent making sure the EFIS was level with the airframe. Some shimming of the EFIS tray installation was requires. Of coarse we had to do some pitot and static line re-routing, but we would have for just installing the EFIS anyway.
The second thing we spent a lot of time on was locating the the remote compass. We located it the fuselage midway between the baggage compartment bulkhead and the horizontal stab. In our A/C this area has no magnetic influences and the installation of support brackets and the unit itself was done using non-magnetic hardware. I guess what took the longest was to come up with a method for the remote compass to be installed with some kind of adjustable attachment (for level adjustability), then ensuring the remote compass was indeed level with the fuselage (with the fuselage level in roll and pitch), and that it was also exactly 90 degress in orientation to the instrument panel. For that we used a very large builders square on the panel and shot a lazer line down the square to the remote compass.
We didn't install at this time the AOA/Pitot probe, but if we had it again would have taken some time as there is a pneumatic line for the AOA to would have to be run from the pitot location (on the L/H wing) to the panel/EFIS.
Although it can be as easy as just installing the EFIS alone in the panel and making a power and ground connection, with all the other stuff like OAT sensor, remote compass and AOA sensor, these things do take time to plan and to install.