Let's come at this from a different perspective.
Independent control of boost, rpm and mixture becomes particularly important when flying for maximum range. Not only is flying at the right speed important, but also reducing fuel consumption, which is best achieved at low rpm, high boost and lean mixture.
Now, just in case you are thinking "I never fly for maximum range" let's consider the case where you are over water and suddenly discover that a fuel drain has been leaking for the last half an hour or so and you are now in a critical fuel state.
So, having flown across the occassional ocean in my time, here is how you handle it.
Immediately switch to only the leaking tank, if it has fuel left in it, that way you use all the fuel you can before you lose it.
Slow down to best range speed, this is almost always about 1.7 VS, so if you don't know the correct speed, (you really should), but you know what speed you stall "power off" in clean configuration, 1.7 times that speed is going to be close enough.
Reduce the rpm as far as you can, most light aircraft engines will come down to about 1900 RPM with reasonable boost, increase boost until the aircraft just flies level at 1.7 Vs and readjust the rpm to as low a value as possible.
We all know, don't we, that lean mixture produces high EGT and CHT temperatures, but leaned beyond peak, these temperatures cool down again! If you lean to the point where the engine runs rough and then richen until it just runs smoothly, you are flying as economically as you can, without over-temping the engine. Monitor CHT and EGT carefully and increase RPM slightly if they get too high.
"In extremis" remember that it takes power and fuel to carry weight, so, if safe to do so, jettison everything but the passengers and the liferaft!
As you burn fuel, Vs decreases, so should your speed and power. Done properly, you will be amazed at how much your "Air Miles per Gallon" will improve. I can't garuantee that you will make it, but you will maximise your chances.
The point of this discourse? You simply don't have that level of control with a single lever!