Without an AHRS, you don't have pressure altitude for the transponder, so you will need an external encoder.
Additionally, the automatic air/ground switching will not work with the transponder.
On the GPS map, on the ground, the map may jump around since it cannot stabilize itself with magnetic heading.
So lots of little things, but no deal killers if you really want an install like that.
If you are considering this for a certified plane, note that we cannot promise the transponder would pass any scrutiny for the 2020 ADS-B out mandate. The transponder has a different part number than other Trig units, and that may cause paperwork issues. Technically it is identical of course.